Deep brain stimulation for tremor resulting from acquired brain injury. Issue 7 (4th December 2013)

• Record Type: Journal Article
• Authors: Sitsapesan, H A; Holland, P; Oliphant, Z; De Pennington, N; Brittain, J-S; Jenkinson, N; Joint, C; Aziz, T Z; Green, A L
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 85:Issue 7(2014)
• Page Start: 811
• Page End: 815
• Publication Date: 2013-12-04
• Subjects: Head Injury -- Tremor -- Neurosurgery -- Movement Disorders -- Electrical Stimulation; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2013-305340
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objectives: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI). Methods: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale. Results: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia. Conclusion: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.