Acarboxyprothrombin concentration [corrected] after oral prophylactic vitamin K. Issue 9 (September 1987)

• Record Type: Journal Article
• Authors: von Kries, R; Kreppel, S; Becker, A; Tangermann, R; Göbel, U
• Is Part Of: Archives of disease in childhood. Volume 62:Issue 9(1987)
• Page Start: 938
• Page End: 940
• Publication Date: 1987-09
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.62.9.938
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : The effect of prophylaxis with oral vitamin K (1 mg vitamin K1 given with the first feed) on the rate of detection of acarboxyprothrombin (PIVKA II) and factor II clotting concentration [corrected] were analysed. Introducing such prophylaxis reduced the rates of detection of PIVKA II concentration [corrected] on day 5 from 48% to zero. None of the babies given prophylaxis had factor II clotting concentration [corrected] below 40%, compared with 34 of 95 babies not given prophylaxis. This study has important implications in the prophylaxis of both classical and late onset haemorrhagic disease of the newborn.