Validity of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma: A Retrospective Pathology-Matched Study. Issue 9 (1st November 2014)

• Record Type: Journal Article
• Authors: Dong, Yu; Wang, Xiaoyun; Wang, Yanan; Liu, Yuan; Zhang, Jiawen; Qian, Wenyan; Wu, Sufang
• Is Part Of: International journal of gynecological cancer. Volume 24:Issue 9(2014)
• Page Start: 1642
• Page End: 1647
• Publication Date: 2014-11-01
• Subjects: 18F-FDG PET/CT -- Cervical carcinoma -- Retrospective -- Pathology matched; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000000287
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: The aim of this study was to evaluate the validity of 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed tomography (CT) for pretreatment evaluation of patients with cervical carcinoma. Methods: Retrospective evaluation of 63 patients, diagnosed with stage IA-IIA cervical carcinoma who underwent 18 F-FDG PET/CT before surgery, was performed. Sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratios (LRs) of PET/CT for predicting the positive cervix, vagina, uterine body, and lymph node invasion at the surgical specimen was calculated. Results: Sensitivity, specificity, positive predictive value, and negative predictive value of the positive cervix invasion in PET/CT to detect positive surgical specimen were 88.2%, 75%, 93.8%, and 60%, respectively. The LR+ ratio was 3.5, and the LR− ratio was 0.2. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive vagina invasion in PET/CT to detect positive surgical specimen were 100%, 70.97%, 5.3%, and 100%, respectively. The LR+ ratio was 3.4, and the LR− ratio was 0. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive uterine body invasion in PET/CT to detect positive surgical specimen were 75%, 83.1%, 23.1%, and 98%, respectively. The LR+ ratio was 4.4, and the LR− ratio was 0.3. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive lymph node invasion in PET/CT to detect positive surgical specimen were 87.5%, 78.4%, 38.9%, and 97.6%, respectively. The LR+ ratio was 4.1, and the LR− ratio was 0.2. Conclusions: The cervix invasion, negative uterine body invasion, and negative lymph node invasion are effective 18 F-FDG PET/CT findings.