Breathless on bortezomib. (18th August 2011)

• Record Type: Journal Article
• Authors: O'Riordan, Devaki; Houghton, John; Chisholm, Roger; O'Driscoll, B Ronan
• Is Part Of: BMJ case reports. Volume 2011
• Publication Date: 2011-08-18
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr.03.2011.4028
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : The authors describe a case of episodic acute pneumonitis occurring after repeated doses of bortezomib, a drug being used increasingly to treat multiple myeloma. The delay in presentation each time with fever, dyspnoea, hypoxia and interstitial radiological changes contributed to under-recognition of this complication, which has so far been described in only a handful of patients, but the pattern seen may offer clues to pathogenesis and potential treatments. This case highlights the need for both physicians and patients consenting to bortezomib treatment to be more aware of this potentially fatal adverse effect.