SAT0081 Lack of Correlation Between Carotid Ultrasound and Disease Duration or Specific Features of Rheumatoid Arthritis. (9th June 2015)

• Record Type: Journal Article
• Authors: Santos Gόmez, M.; Corrales, A.; Riancho-Zarrabeitia, L.; Rueda-Gotor, J.; Blanco, R.; Pina, T.; González-Gay, M. Ά.
• Is Part Of: Annals of the rheumatic diseases. Volume 74(2015)Supplement 2
• Page Start: 677
• Page End: 678
• Publication Date: 2015-06-09
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2015-eular.5658
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Patients with Rheumatoid Arthritis (RA) have an increased risk of atherosclerosis and cardiovascular disease (CD) when compared with the general population. Objectives: We assessed if the inflammatory burden, the disease activity as well as specific features of the disease correlate with the presence of subclinical atherosclerosis in patients with RA. Methods: A cohort of patients with RA without cardiovascular events was studied in a tertiary University Hospital. Carotid ultrasonography was performed by a MyLab 70 scanner (Esaote; Genoa, Italy), equipped with 7–12 MHz linear transducer and the automated software guided technique radiofrequency – Quality Intima Media Thickness in real-time (QIMT, Esaote, Maastricht, Holland) to determine carotid intima-media thickness (cIMT) and plaques, according to the Mannheim Carotid Intima-Media Thickness Consensus. We analyzed disease duration (>2 years, 2-10, >10 years), rheumatoid Factor (RF) and anti-cyclic citrullinated peptide antibodies (ACPA) status, and PCR and ESR. DAS28 and SDAI were calculated. Logistic regression analyses were performed. Results: We assessed 592 patients with RA (456 women/136 men; mean age 59±13 years) without history of cardiovascular events. Among them, 55% and 47% of patients had RF+ and ACPA+ respectively (61% were RF+ and/or ACPA +). The prevalence of plaques was not increased in RF+ and/or ACPA+ patients: OR: 1.02 [0.73-1.43] or in those with erosions on plain radiograph: OR: 1.03 [0.74-1.45]. A significant correlation between the mean CRP values in the last 5 years prior to carotid ultrasound and the cIMT (p=0.012) or the presence of carotid plaques (p=0.006) was found. However, this significant correlation was not observed after adjustment for age and smoking. No correlation between carotid ultrasound and DAS28 and SDAI was found. Conclusions: Our study does not support a correlation between subclinical atherosclerosis assessed by carotid ultrasound and disease duration or specific features of RA. Disclosure of Interest: None declared