Copper‐Catalyzed Regioselective Borocarbonylative Coupling of Unactivated Alkenes with Alkyl Halides: Synthesis of β‐Boryl Ketones. (28th April 2020)

• Record Type: Journal Article
• Authors: Wu, Fu‐Peng; Yuan, Yang; Schünemann, Claas; Kamer, Paul C. J.; Wu, Xiao‐Feng
• Is Part Of: Angewandte Chemie. Volume 132:Number 26(2020)
• Page Start: 10537
• Page End: 10541
• Publication Date: 2020-04-28
• Subjects: alkene -- borocarbonylation -- borofunctionalization -- carbonylative coupling -- copper catalyst; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202002714
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The borocarbonylative coupling of unactivated alkenes with alkyl halides remains a challenge. In this communication, a Cu‐catalyzed borocarbonylative coupling of unactivated alkenes with alkyl halides for the synthesis of β‐boryl ketones has been developed. A broad range of β‐boryl ketone derivatives was prepared in moderate to excellent yields with complete regioselectivity. Abstract : The borocarbonylative coupling of unactivated alkenes with alkyl halides remains a challenge. In this communication, a Cu‐catalyzed borocarbonylative coupling of unactivated alkenes with alkyl halides for the synthesis of β‐boryl ketones has been developed. A broad range of β‐boryl ketone derivatives was prepared in moderate to excellent yields with complete regioselectivity.