Specific "Unlocking" of a Nanozyme‐Based Butterfly Effect To Break the Evolutionary Fitness of Chaotic Tumors. Issue 24 (1st April 2020)

• Record Type: Journal Article
• Authors: Zhen, Wenyao; Liu, Yang; Wang, Wei; Zhang, Mengchao; Hu, Wenxue; Jia, Xiaodan; Wang, Chao; Jiang, Xiue
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 24(2020)
• Page Start: 9491
• Page End: 9497
• Publication Date: 2020-04-01
• Subjects: antitumor agents -- butterfly effect -- chaotic tumors -- iridium oxide -- parallel cascade reactions; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201916142
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Chaos and the natural evolution of tumor systems can lead to the failure of tumor therapies. Herein, we demonstrate that iridium oxide nanoparticles (IrO x ) possess acid‐activated oxidase and peroxidase‐like functions and wide pH‐dependent catalase‐like properties. The integration of glucose oxidase (GOD) unlocked the oxidase and peroxidase activities of IrO x by the production of gluconic acid from glucose by GOD catalysis in cancer cells, and the produced H2 O2 was converted into O2 to compensate its consumption in GOD catalysis owing to the catalase‐like function of the nanozyme, thus resulting in the continual consumption of glucose and the self‐supply of substrates to generate superoxide anion and hydroxyl radical. Moreover, IrO x can constantly consume glutathione (GSH) by self‐cyclic valence alternation of Ir IV and Ir III . These cascade reactions lead to a "butterfly effect" of initial starvation therapy and the subsequent pressure of multiple reactive oxygen species (ROS) to completely break the self‐adaption of cancer cells. Abstract : Conquering chaos : IrO x nanoparticles were shown to possess acid‐activated multienzyme‐like properties, and further loading with glucose oxidase (GOD) created a nanozyme (IrO x –GOD) that mimicked four enzymes. The introduction of IrO x –GOD into chaotic tumors led to a "butterfly effect" of initial starvation therapy and subsequent pressure of multiple reactive oxygen species (ROS) to completely disrupt the self‐adaption of cancer cells (see picture).