Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross‐Sectional Study. Issue 6 (14th May 2020)

• Record Type: Journal Article
• Authors: Fernández‐Carballido, Cristina; Martín‐Martínez, María A.; García‐Gómez, Carmen; Castañeda, Santos; González‐Juanatey, Carlos; Sánchez‐Alonso, Fernando; García de Vicuña, Rosario; Erausquin‐Arruabarrena, Celia; López‐Longo, Javier; Sánchez, María D.; Corrales, Alfonso; Quesada‐Masachs, Estefanía; Chamizo, Eugenio; Barbadillo, Carmen; Bachiller‐Corral, Javier; Cobo‐Ibañez, Tatiana; Turrión, Ana; Giner, Emilio; Llorca, Javier; González‐Gay, Miguel A.
• Other Names: Gonzalez de Rabago Eugenia investigator.; Blanco Morales Elena Alonso investigator.; Fernández Lopez J. Carlos investigator.; Oreiro Villar Natividad investigator.; Atanes Sandoval Antonio investigator.; Blanco García Francisco J. investigator.; Alegre De Miquel Cayetano investigator.; González Fernández María J. investigator.; Codina Ramón Huguet investigator.; Yoldi Beatriz investigator.; Ramentol Mercedes investigator.; Ávila Gabriela investigator.; Marsal Barril Sara investigator.; Steiner Martina investigator.; Muñoz Santiago investigator.; Gamero Fernando investigator.; García Torón José investigator.; Espino Pilar investigator.; Ros Inmaculada investigator.; Ibáñez Mónica investigator.; Murillo Claudia investigator.; Molina Jesús Tornero investigator.; Sanmartí Raimon investigator.; Berman Horacio investigator.; Cabrera Sonia investigator.; Ruiz Virginia investigator.; Patón Oscar Fontseré investigator.; Fernández Gutierrez Benjamín investigator.; Abasolo Lydia investigator.; Pina Jose Manuel investigator.; Nolla Joan M. investigator.; García Arias Miriam investigator.; Uriarte‐Ecenarro Mirem investigator.; García Vadillo Jesús A. investigator.; Fernández Nebro Antonio investigator.; Manrique Arija Sara investigator.; Belmonte López María Angeles investigator.; Ureña Inmaculada investigator.; Irigoyen María V. investigator.; Cagigal Virginia Coret investigator.; Garrido Daniel Pielfort investigator.; García Aparicio Angel María investigator.; Belmonte Gómez Rebeca investigator.; Bautista Pastora Granados investigator.; Hernandez Sanz Azucena investigator.; Manero Francisco J. investigator.; Jimenez Zorzo Fernando investigator.; Giménez Ubeda Eugenio investigator.; Gracía Jesús Marzo investigator.; Audera Chesús Beltrán investigator.; Medrano Marta investigator.; Pecondón Ángela investigator.; Ojeda Soledad investigator.; Quevedo Juan Carlos investigator.; Francisco Félix investigator.; Rodríguez Lozano Carlos investigator.; Gerona Delia investigator.; González Fernández Carlos investigator.; Carreño Luis investigator.; Monteagudo Indalecio investigator.; del Pino Javier investigator.; Peiró María Enriqueta investigator.; Fernández‐Carballido Cristina investigator.; Senabre José M. investigator.; Rosas José C. investigator.; Rotés Isabel investigator.; Moreno Estefanía investigator.; Erra Alba investigator.; Grado Dolors investigator.; Calvo Javier investigator.; Rueda Amalia investigator.; Möller Ingrid investigator.; Rodríguez Isabel investigator.; Raya Enrique investigator.; Morales Pilar investigator.; Nieto Ana investigator.; Jiménez Inmaculada investigator.; Magro Cesar investigator.; Ruibal Escribano Ana investigator.; Expósito Sergio Ros investigator.; Sánchez Nievas Ginés investigator.; Navarro Enrique Júdez investigator.; Sianes Fernández Manuela investigator.; García Morales María Angeles investigator.; Bastero Isabel Labiano investigator.; Consuegra Gloria García investigator.; Palmou Natalia investigator.; Pardo Silvia Martínez investigator.; Pujol Manel investigator.; Alonso Elena Riera investigator.; Salvador Georgina investigator.; González Alvarez Beatriz investigator.; Cantabrana Alberto investigator.; Bustabad Sagrario investigator.; Delgado Esmeralda investigator.; Muñoz Alejandro investigator.; Montero Sergio Rodriguez investigator.; Jimenez Luis María investigator.;
• Is Part Of: Arthritis care & research. Volume 72:Issue 6(2020)
• Page Start: 822
• Page End: 828
• Publication Date: 2020-05-14
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.23910
• Languages: English
• ISSNs: 2151-464X

Abstract

Abstract : Objective: To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Methods: This was a cross‐sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0–27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and P values. Results: We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (β = 0.11). Also, female sex (β = 0.14), disease duration (β = 0.01), disease activity (DAS28‐ESR; β = 0.19), and the use of nonsteroidal antiinflammatory drugs (β = 0.09), glucocorticoids (β = 0.11), and biologics (β = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (β = –0.14). In patients with AS, age (β = 0.03), disease activity (BASDAI; β = 0.81), radiographic damage (β = 0.61), and the use of biologics (β = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. Conclusion: The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.