HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease. Issue 1 (23rd December 2003)

• Record Type: Journal Article
• Authors: Cole, G; Coleman, N; Soilleux, E
• Is Part Of: Journal of clinical pathology. Volume 57:Issue 1(2004)
• Page Start: 79
• Page End: 80
• Publication Date: 2003-12-23
• Subjects: DC-SIGN -- DC-SIGNR -- hepatitis C -- liver sinusoid; DC, dendritic cell -- DC-SIGN, dendritic cell specific intercellular adhesion molecule grabbing non-integrin -- DC-SIGNR, dendritic cell specific intercellular adhesion molecule grabbing non-integrin related molecule -- HCV, hepatitis C virus -- HIV, human immunodeficiency virus; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.57.1.79
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : The process by which hepatitis C virus (HCV) enters cells and the reason for its hepatotropism remain obscure. Recently, the human immunodeficiency virus (HIV) binding lectins, DC-SIGN and DC-SIGNR, were shown to bind HCV. This article reports the expression of DC-SIGN and DC-SIGNR in HCV related liver disease and discusses whether these lectins, in particular DC-SIGNR, are responsible for HCV hepatotropism.