Vitamin D status during pregnancy and in cord blood in a large prospective French cohort. Issue 5 (October 2019)

• Record Type: Journal Article
• Authors: Courbebaisse, Marie; Souberbielle, Jean-Claude; Baptiste, Amandine; Taieb, Joëlle; Tsatsaris, Vassilis; Guibourdenche, Jean; Senat, Marie-Victoire; Haidar, Hazar; Jani, Jacques; Guizani, Meriem; Jouannic, Jean-Marie; Haguet, Marie-Clotilde; Winer, Norbert; Masson, Damien; Elie, Caroline; Benachi, Alexandra
• Is Part Of: Clinical nutrition. Volume 38:Issue 5(2019)
• Page Start: 2136
• Page End: 2144
• Publication Date: 2019-10
• Subjects: Vitamin D -- Pregnancy -- Newborns -- Epidemiology -- Supplementation; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2018.08.035
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Vitamin D status during pregnancy and in newborns has never been studied in France. This study aims at determining the vitamin D status during the first and third trimesters of pregnancy (T1, T3) and in cord blood (CB) in the middle-north of France. Methods: We conducted a prospective cohort study in five French centers (latitude 47.22 to 48.86°N). Serum 25(OH)-vitamin D (25(OH)D) concentrations were measured using a radioimmunoassay during T1, T3 and in CB. According to the French guidelines, pregnant women received cholecalciferol, 100, 000 IU, in the seventh month. Results: Between April 2012 and July 2014, 2832 women were included, of whom 2803 were analyzed (mean ± SD age: 31.5 ± 5.0 years; phototypes 5–6: 21.8%). Three and 88.6% of participants received supplementation during the month before inclusion and in the seventh month, respectively. At T1, T3, and CB, mean 25(OH)D concentrations were 21.9 ± 10.4, 31.8 ± 11.5, and 17.0 ± 7.2 ng/mL, respectively, and 25(OH)D was <20 ng/mL in 46.5%, 14.0%, and 68.5%, respectively. At T1, body mass index ≥25 kg/m 2, dark phototypes, sampling outside summer, and no supplementation before inclusion were independently associated with vitamin D insufficiency (25(OH)D < 20 ng/mL). Women who received cholecalciferol supplementation in month 7 had higher 25(OH)D at T3 than non-supplemented women (32.5 ± 11.4 versus 25.8 ± 11.4 ng/mL, p = <0.001) and marginally higher 25(OH)D in CB (17.2 ± 7.2 versus 15.5 ± 7.1 ng/mL, p = 0.004). Conclusions: Despite the recommended supplementation, vitamin D insufficiency is frequent during pregnancy and in newborns in France.