Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. Issue 6047 (27th November 1976)

• Record Type: Journal Article
• Authors: Drasar, F A; Farrell, W; Maskell, J; Williams, J D
• Is Part Of: BMJ. Volume 2:Issue 6047(1976)
• Page Start: 1284
• Page End: 1287
• Publication Date: 1976-11-27
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.2.6047.1284
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin.