Prenylated flavonoid‐standardized extract from seeds of Psoralea corylifolia L. activated fat browning in high‐fat diet–induced obese mice. (22nd May 2019)

• Record Type: Journal Article
• Authors: Liu, Jingwen; Zhao, Yuanyuan; Huang, Cheng; Li, Yiming; Guo, Fujiang
• Is Part Of: Phytotherapy research. Volume 33:Number 7(2019)
• Page Start: 1851
• Page End: 1864
• Publication Date: 2019-05-22
• Subjects: anti‐obesity -- brown adipose tissue -- prenylated flavonoids -- Psoralea corylifolia L -- white adipose tissue; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.6374
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : We investigated the effects of the prenylated flavonoid‐standardized extract (PFE) from the seeds of Psoralea corylifolia L. on countering obesity, which increases energy expenditure and stimulates thermogenesis in subcutaneous white adipose tissue (sWAT) and brown adipose tissue (BAT). For 12 weeks, C57BL/6 mice were fed a controlled high‐fat diet (HFD) or HFDs with 0.2% or 0.5% w /w PFE. In vitro, the differentiation of 3 T3‐L1 cells was used to elicit thermogenesis in the presence of PFE. PFE obviously reduced body weight and fat mass in a dose‐dependent manner, increased energy expenditure, improved insulin sensitivity, and prevented hepatic steatosis by increasing lipid oxidation and secretion in HFD‐fed mice. Moreover, PFE induced clear browning in sWAT, significantly increased phosphorylation of AMPK α 1/2 and p38, increased BAT activity and the differentiation of 3 T3‐L1 by increasing the expression of uncoupling protein 1 and other thermogenic genes. Our study showed that PFE prevented obesity by increasing browning and activating thermogenic genes in sWAT and BAT, improving glucose homeostasis, and protecting hepatic steatosis.