Conjugated equine oestrogens and blood clotting: a follow-up report. Issue 6066 (9th April 1977)

• Record Type: Journal Article
• Authors: Poller, L; Thomson, J M; Coope, J
• Is Part Of: BMJ. Volume 1:Issue 6066(1977)
• Page Start: 935
• Page End: 936
• Publication Date: 1977-04-09
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.1.6066.935
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : A follow-up study of blood clotting and platelet aggregation was performed on 21 women who had received long-term hormone replacement treatment with conjugated equine oestrogens. The prothrombin time and factor VII and X values were significantly accelerated after three months, but there was no further increase with continual administration for 18 months. After 12 to 18 months' treatment, however, thrombin-induced platelet aggregation (Chandler's tube) was also significantly accelerated, which suggested a widening spectrum of effect. No overall acceleration of "intrinsic" clotting (partial thromboplastin time and thromboelastography) was found during the study, but the relatively small numbers may have been responsible. Further efforts are therefore required to find formulations and doses of oestrogens which, while relieving menopausal symptoms, cause less acceleration of blood clotting and platelet aggregation.