Childhood Hyperlipidemia and its Association with Early Growth Among Full‐Term–Born Children at 5 to 6 Years of Age in China. Issue 8 (23rd June 2020)

• Record Type: Journal Article
• Authors: Li, Weiqin; Leng, Junhong; Wang, Shuting; Wang, Leishen; Wang, Shuo; Zhang, Tao; Qiao, Yijuan; Mi, Jie
• Is Part Of: Obesity. Volume 28:Issue 8(2020)
• Page Start: 1526
• Page End: 1535
• Publication Date: 2020-06-23
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.22840
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: This study's aim was to assess the prevalence of hyperlipidemia and its association with birth weight and BMI at 2 years of age and 5 to 6 years of age in full‐term–born children. Methods: A population‐based, large‐scale survey of hyperlipidemia was conducted. Information on 12, 701 children aged 5 to 6 years was retrospectively collected from electronic health care records. Results: The rate of high total cholesterol (≥5.18 mmol/L) and/or high triglycerides (≥1.70 mmol/L) was 10.2%. The multivariate‐adjusted odds ratios of high total cholesterol and/or triglycerides were 1.33 (1.04‐1.69), 1.00, and 0.95 (0.81‐1.11) based on birth weight groups (small for gestational age [SGA], appropriate for gestational age, and large for gestational age); 1.06 (0.77‐1.45), 1.00, and 0.99 (0.88‐1.11) based on BMI groups at around 2 years of age (<10th, 10th to <75th, and ≥75th percentiles); and 1.56 (1.08‐2.25), 1.00, and 1.71 (1.44‐2.03) based on BMI groups at 5 to 6 years of age (<−2 SD, −2 SD to <2 SD and ≥2 SD), respectively. In the SGA group, hyperlipidemia was not associated with BMI at 2 years of age but was significantly associated with having underweight or obesity at 5 to <6 years of age. Conclusions: SGA infants are at an increased risk for childhood hyperlipidemia, and catch‐up growth before the age of 2 years would not affect this risk. For SGA infants, having underweight or obesity after 2 years of age can increase the risk of childhood hyperlipidemia.