Survival and specific outcome of sickle cell disease patients after renal transplantation. (26th July 2019)

• Record Type: Journal Article
• Authors: Gérardin, Christel; Moktefi, Anissa; Couchoud, Cécile; Duquesne, Alyette; Ouali, Nacera; Gataut, Philippe; Karras, Alexandre; Anglicheau, Dany; Lefaucheur, Carmen; Figueres, Lucile; Albano, Laetitia; Lionet, Arnaud; Novion, Marine; Ziliotis, Marie‐Julia; Louis, Magali; Del Bello, Arnaud; Matignon, Marie; Dahan, Karine; Habibi, Anoosha; Galacteros, Frederic; Bartolucci, Pablo; Grimbert, Philippe; Audard, Vincent
• Is Part Of: British journal of haematology. Volume 187:Number 5(2019)
• Page Start: 676
• Page End: 680
• Publication Date: 2019-07-26
• Subjects: sickle cell disease -- renal transplantation -- patient survival -- infections; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.16113
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: The prognosis of sickle cell disease (SCD) patients who need dialysis is poor, but experience with kidney transplantation is limited. This study assessed the characteristics of 36 SCD patients undergoing renal transplantation. Immediate post‐surgical complications occurred in 25% of cases. Cytomegalovirus and bacterial infections were frequently observed. Twelve patients died after a median follow‐up period of 17·4 months. Overall patient survival was significantly lower in SCD than in the control group without significant difference for overall death‐censored graft survival. Our data suggest that renal transplantation should be systematically considered in SCD patients with end‐stage renal disease.