Iron‐porphyrin Catalyzed Carbene Transfer Reactions – an Evolution from Biomimetic Catalysis towards Chemistry‐inspired Non‐natural Reactivities of Enzymes. Issue 8 (24th January 2020)

• Record Type: Journal Article
• Authors: Weissenborn, Martin J.; Koenigs, Rene M.
• Is Part Of: ChemCatChem. Volume 12:Issue 8(2020)
• Page Start: 2171
• Page End: 2179
• Publication Date: 2020-01-24
• Subjects: iron -- carbine -- diazoalkane -- biocatalysis -- directed evolution; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201901565
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract: Bioinspired, synthetic porphyrin complexes are important catalysts in organic synthesis and play a pivotal role in efficient carbene transfer reactions. The advances in this research area stimulated recent, "chemo‐inspired" developments in biocatalysis. Today, both synthetic iron complexes and enzymes play an important role to conduct carbene transfer reactions. The advances and potential developments in both research areas are discussed in this concept article. Abstract : Carbene transfer reactions : Iron complexes have recently emerged as catalysts to conduct efficient carbene transfer reactions with diazoalkanes. In this concept, the latest developments in this research area and highlight requirements and advances on both synthetic and enzymatic iron catalysts are discussed. It concludes with the latest developments in iron‐catalyzed C−H bond functionalization reactions.