COX‐2 gene polymorphisms and risk of chronic periodontitis: a case–control study and meta‐analysis. (25th November 2013)

• Record Type: Journal Article
• Authors: Prakash, G; Umar, M; Ajay, S; Bali, D; Upadhyay, R; Gupta, KK; Dixit, J; Mittal, B
• Is Part Of: Oral diseases. Volume 21:Number 1(2015:Jan.)
• Page Start: 38
• Page End: 45
• Publication Date: 2013-11-25
• Subjects: cyclooxygenase‐2 -- meta‐analysis -- periodontitis -- susceptibility; Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12203
• Languages: English
• ISSNs: 1354-523X

Abstract

Abstract : Objective: Cyclooxygenase‐2 (COX‐2) enzyme is a major mediator of inflammation in periodontitis, leading to loss of gingival tissues and alveolar bone supporting the teeth. Previous studies have explored the role of COX‐2 polymorphisms with the risk of periodontitis in different ethnic groups; however, findings are inconsistent. So, we aimed to investigate the association of COX‐2 polymorphisms (rs20417, rs689466, and rs5275) in susceptibility to chronic periodontitis (CP) in northern Indian population. Meta‐analysis was also carried out to precisely estimate the effect of COX‐2 polymorphisms in CP. Materials and Methods: Genotyping of COX‐2 polymorphisms was carried out through PCR‐RFLP in 200 CP cases and 200 controls. For risk estimation, binary logistic regression was applied using SPSS, version 15.0, while meta‐analysis was carried using MIX 2.0 software. Results: None of the COX‐2 polymorphisms independently were associated with the risk of CP. Meta‐analysis suggested a significant reduced risk of CP with rs5275+8473 C allele and rs20417 in Chinese population. Conclusions: No association was observed in any of the studied COX‐2 polymorphisms with CP in North India. But, the study should be replicated in larger sample size to arrive at a definitive conclusion. Meta‐analysis suggested a role of rs5275 COX‐2 polymorphisms in susceptibility to overall CP, and on ethnic basis, rs20417 showed reduced risk of CP in Chinese population.