T-Cell–Rich Recurrence of Primary Cutaneous Follicle Center Lymphoma After Systemic Rituximab: A Diagnostic Pitfall. (March 2020)

• Record Type: Journal Article
• Authors: Santonja, Carlos; Prieto-Torres, Lucía; Pérez-Sáenz, María de los Ángeles; Requena, Luis; Rodríguez-Pinilla, Socorro-María
• Is Part Of: American journal of dermatopathology. Volume 42:Number 3(2020)
• Publication Date: 2020-03
• Subjects: cutaneous follicle center lymphoma -- skin -- rituximab -- histopathology -- recurrence; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000001544
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: We report on a 74-year-old man with a cutaneous B-cell follicle center lymphoma, which was treated upfront with systemic rituximab and suffered several local relapses. The first of the local recurrences, 10 months after completion of treatment, was characterized by a dense T-cell infiltrate that obscured a minor population of B-cell lymphoma cells, suggesting a second primary cutaneous T-cell lymphoma. This represents a previously not reported diagnostic pitfall and underscores the importance of performing sequential biopsies when dealing with lymphoma recurrences in this setting.