Growth hormone release inhibiting hormone: actions on thyrotrophin and prolactin secretion after thyrotrophinreleasing hormone. Issue 5975 (12th July 1975)

• Record Type: Journal Article
• Authors: Carr, D; Gomez-Pan, A; Weightman, D R; Roy, V C; Hall, R; Besser, G M; Thorner, M O; McNeilly, A S; Schally, A V; Kastin, A J; Coy, D H
• Is Part Of: BMJ. Volume 3:Issue 5975(1975)
• Page Start: 67
• Page End: 69
• Publication Date: 1975-07-12
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.3.5975.67
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The hypothalamic tetradecapeptide growth hormone release inhibiting hormone (GH-RIH) blocked the thyrotrophin response to thyrotrophin-releasing hormone (TRH) in normal people and in patients with primary hypothyroidism. This inhibition was dose related. The TRH-induced prolactin release was not affected by GH-RIH. This dissociation of the thyrotrophin and prolactin responses to TRH by GH-RIH suggests that there are different mechanisms for release of thyrotrophin and prolactin and that only the former is affected by GH-RIH.