Pain behavior without pain sensation: an epileptic syndrome of "symbolism for pain"?. Issue 3 (March 2020)

• Record Type: Journal Article
• Authors: Hagiwara, Koichi; Garcia-Larrea, Luis; Tremblay, Léon; Montavont, Alexandra; Catenoix, Hélène; Rheims, Sylvain; Guénot, Marc; Isnard, Jean
• Is Part Of: Pain. Volume 161:Issue 3(2020)
• Publication Date: 2020-03
• Subjects: Pain symbolism -- Posterior insulo-opercular seizures -- Stereoelectroencephalography -- Behavioral networks of pain; Pain -- Periodicals; Douleur -- Périodiques; Anesthésie -- Périodiques; Pain; Electronic journals; Periodicals; Electronic journals; 616.0472
• DOI: 10.1097/j.pain.0000000000001741
• Languages: English
• ISSNs: 0304-3959

Abstract

Abstract : Abstract: "Asymbolia for pain" has shown the potentiality of diseased insular networks to dissociate sensory from affective-behavioral dimensions of pain, resulting in the lack of appropriate motor and affective responses despite preserved sensory aspect of pain. Here, we describe 4 patients with an inverse phenomenon of asymbolia for pain, namely an isolated "symbolism for pain" triggered by epileptic seizures, characterized by pain behavior without declarative pain sensation despite fully preserved contact and vigilance. Stereoelectroencephalography demonstrated in each case focal seizure discharges within the posterior insulo-opercular cortex, with little or no propagation to other cortical structures, especially those considered to drive subjective pain experiences. The pain behavior might reflect seizure propagation from the insula to brain networks serving for behavioral responses associated with pain, including the cingulate motor region and possibly also the basal ganglia. We propose that the isolated symbolism for pain is a novel epileptic syndrome of dissociation between pain perception and behaviors associated with the insular nociceptive-related networks. Abstract : Supplemental Digital Content is Available in the Text.Seizures of posterior insulo-opercular origin can manifest solely as behavioral expressions of pain without actual pain sensation (=isolated "symbolism for pain").