D07 Levels Of The Light Subunit Of Neurofilatment Protein In Cerebrospinal Fluid In Huntington's Disease. (17th September 2014)

• Record Type: Journal Article
• Authors: López-Sendón, J; Picón, C; García-Caldentey, J; García de Yébenes, J; Álvarez-Cermeño, JC; Villar, LM
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 85(2014)Supplement 1
• Page Start: A34
• Page End: A34
• Publication Date: 2014-09-17
• Subjects: Cerebrospinal fluid -- Neurofilament -- Huntington's Disease; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2014-309032.99
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Introduction: Light subunit of neurofilament protein (NFL) is a structural element of neurons. Its levels are increased in cerebrospinal fluid (CSF) in the setting of neurological diseases, including Huntington's disease (HD), and are considered a marker of neuronal damage. HD is a paradigm of neurodegeneration in the need of appropriate biomarkers. Objectives: To compare the levels of CSF-NFL of HD patients and healthy controls. To correlate CSF-NFL levels with demographic and clinical variables. Methods: The ELISA for NFL was performed according to previously published methods. Twenty-four HD participants (11 women; mean age 47.3 (SD 12.3)) and 37 controls (26 women; mean age 34.1 (SD 9.4)) were included. We compared levels of NFL-CSF levels with a regression model adjusted for age and gender. We examined the relationships (Pearson correlations) between NFL-CSF levels and demographic (age, gender) and clinical (CAG repeat number, disease burden, UHDRS motor, behavioural, functional total scores and NPI scale) variables. Results: CSF levels were significantly higher in all HD subjects [5014.4 (1557.3) ng/l] as compared to controls [335.4 (193.3) ng/l] (p < 0.00) and were correlated with age (correlation coefficient -0.37, p < 0.01) and CAG triplet number (0, 51, p < 0.05) in the subset of HD patients. We did not find any correlation with the remaining variables. Conclusions: These results indicate that NFL-CSF levels is a marker of neuronal damage in HD and warrant future efforts towards establishing its sensitivity to track disease progression and reactivity to therapeutical interventions.