I20 The assessment of quality of life in patients with moderately advanced huntington's disease. (13th September 2016)

• Record Type: Journal Article
• Authors: Szejko, Natalia; Milanowski, Lukasz; Jamrozik, Zygmunt; Janik, Piotr
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 87(2016)Supplement 1
• Page Start: A65
• Page End: A66
• Publication Date: 2016-09-13
• Subjects: Quality of life -- disease specific scales; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2016-314597.185
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Background: Huntington's disease (HD) is neurodegenerative disorder that impairs severely everyday functioning. Aim: The aim of the study was to determine if avalaible quality of life scales are useful to detect the deterioration of quality of life in patients with moderate stage of the disease. Methods: We evaluated data of 22 patients with early and moderately advanced HD (average disease duration of 34 months) enrolled in REGISTRY and Enroll-HD studies. SF-36, Total Functional Capacity (TFC), Functional Assessment Scale (FAS) and Independence Scale were performed at initial visit and follow-up after mean 34.6 months. We calculated correlations of these scales with motor symptoms measured with Unified Huntington's Disease Rating Scale (UHDRS) and cognitive state. Results: We did not observe significant deterioration of quality of life measured with any of scales we used. There was an average decrease of 3.38 ± 0.9 in SF-36 (p = 0.49), 2.01 ± 0.71 in TFC (p = 0.17), 1.98 ± 0.71 in FAS (p = 0.23). UHDRS increased from 37.55 to 42.24 (mean 4.69 ± 41, p = 0.54), Reading Test from 57.4 to 52.2 (mean 5.23 ± 7.78, p = 0.37), Symbol Digit Modality Test from 25.68 to 24.18 (mean 1.54 ± 9.9, p = 0.72) Conclusions: All applied quality of life related scales are not sensitive enough to detect significant deterioration of quality of life in patients with short disease duration.