PO203 Assessing disease activity and cardiac involvement in myositis. (1st December 2017)

• Record Type: Journal Article
• Authors: Lilleker, James B; Guy, Mark; Roberts, Mark E; Sergeant, Jamie C; Cooper, Robert G; Chinoy, Hector
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 88(2017)Supplement 1
• Page Start: A65
• Page End: A65
• Publication Date: 2017-12-01
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2017-ABN.224
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Background: Methods of monitoring disease activity and detecting cardiac involvement in myositis are inadequate, contributing to poor outcomes. We investigated the potential for a panel of serum muscle damage markers to address these issues. Methods: Disease activity and cardiac involvement in adult myositis patients was assessed and serum total creatine kinase (CK), cardiac troponin-T (cTnT), cardiac troponin-I (cTnI) and CK-MB were measured. Convergent construct validity assessment using Spearman's ranked correlation and logistic regression were used. Results: Of 46 patients, most had dermatomyositis (39%). The mean age was 52 years. 72% were female. Strongest correlations were observed between cTnT and manual muscle testing scores (rho −0.53, p<0.001), and between CK-MB and the Health Assessment Questionnaire (HAQ) (rho 0.44, p=0.002). Combining an abnormal CK and CK-MB identified a group with a significantly higher HAQ (OR 2.06, 95% CI 1.07–3.97, p=0.031), whereas this was not found in those with an abnormal CK alone. Serum muscle damage marker levels were not significantly different in those with cardiac involvement (n=8) although an abnormal cTnI had 95% specificity for cardiac involvement. Conclusion: When assessing disease activity in myositis, serum cTnT and CK-MB appear useful in addition to total CK, whereas cTnI may assist identification of cardiac involvement.