Hypertensive crisis following the administration of tedizolid: possible serotonin syndrome. Issue 1 (1st December 2018)

• Record Type: Journal Article
• Authors: de Castro Julve, Maria; Miralles Albors, Paula; Ortonobes Roig, Sara; Vives, Roser; Falgueras, Luis; Gómez-Valent, Mònica
• Is Part Of: European journal of hospital pharmacy. Volume 27:Issue 1(2020)
• Page Start: 52
• Page End: 54
• Publication Date: 2018-12-01
• Subjects: adverse effects -- tedizolid -- pharmacological interactions -- hypertensive crisis -- serotonin syndrome; Pharmacy -- Periodicals; Hospital pharmacies -- Periodicals; 615.1
• DOI: 10.1136/ejhpharm-2018-001752
• Languages: English
• ISSNs: 2047-9956

Abstract

Abstract : Thiscase report concerns a 34-year-old male with a hip prosthesis infection, under treatment with antidepressant and antihypertensive drugs, who presented with an increase in blood pressure after four days of treatment with oral tedizolid. Tedizolid was discontinued, and the dose of antihypertensive was increased. The patient progressively achieved the normalisation of blood pressure values, which allowed a reduction in the antihypertensive agent dose to its usual regimen. No cases of hypertension or serotonin toxicity are described in the initial tedizolid studies, where patients treated with other serotonergic drugs were excluded. However, this does not mean that these effects may not occur in clinical practice, especially in patients under concomitant treatment with this type of medication, because of the greater risk of drug interactions. The causality of this suspected drug reaction was analysed and it was considered as possible. The case has been reported to the pharmacovigilance system.