3PC-067 Assessment of cold chain in chemotherapy unit. (March 2019)

• Record Type: Journal Article
• Authors: Villain, A; Vangheluwe, E; Giraud, J; Pingaud, C
• Is Part Of: European journal of hospital pharmacy. Volume 26(2019)Supplement 1
• Page Start: A67
• Page End: A67
• Publication Date: 2019-03
• Subjects: Pharmacy -- Periodicals; Hospital pharmacies -- Periodicals; 615.1
• DOI: 10.1136/ejhpharm-2019-eahpconf.148
• Languages: English
• ISSNs: 2047-9956

Abstract

Abstract : Background: Management of the anticancer treatments remainders is improved thanks to the centralisation of preparations. In our unit, remainders stored at 4°C are placed in transfer containers kept in a refridgerator. Remainders are regularly exposed to ambient temperatures. Today, no transfer system can respect the cold chain of remainders. Purpose: Improvement in practices and respect of the anticancer product's cold chain. Material and methods: A follow-up of container's temperature evolution was carried out over a period of 3 hours, simulating the routine activity: three successive exposures of the container 20 min at ambient temperature followed by 40 min in a refridgerator. These measurements were repeated three times with and without refrigerated eutectic plates for a total of 1080 measurement points. A comparison of temperature's evolution was made with and without eutectic plates. The average of each measurement point, the SD as well as the median and average over the study period, were calculated. Results: The maximum temperatures in the containers were 12.1°C without eutectic plates and 11.1°C with eutectic plates. The remainders from the refridgerator are better preserved thanks to the eutectic plates. In addition, eutectic plates decrease temperature variations in the container with a SD of 2.4°C without ice bread and 1.4°C with eutectic plates. However, the average temperatures in the container were 8.6°C with eutectic plates versus 7.8°C without eutectic plates, and the median was 8.7°C with eutectic plates and 7.5°C without eutectic plates. The temperature of the container with eutectic plates is higher than that without eutectic plates, which is explained by the fact that the container cools less quickly with an eutectic plate. Conclusion: Eutectic plates reduce temperature variations of containers for a half-day of activity but do not offer a satisfactory solution for controlling the cold chain. In the future, industries should provide a solution to this problem to improve the quality of cyotoxic preparations. References and/or acknowledgements: BPP, AFSSAPS 2007. No conflict of interest.