A Near-Infrared Triggered Intracellular pH Regulative PAMAM/O-nitrobenzaldehyde Coated UCNPs for Cancer Therapy. Issue 199 (13th June 2019)

• Record Type: Journal Article
• Authors: Zhou, Liping; Hu, Hao; Zhang, Yi-Xin; Meng, Qing-Ye; Yu, Bing; Shen, You-Qing; Cong, Hai-Lin
• Is Part Of: Integrated ferroelectrics. Issue 199(2019)
• Page Start: 85
• Page End: 94
• Publication Date: 2019-06-13
• Subjects: Dendrimer -- UCNPs -- near infrared -- cellular acidity gradient -- tissue imaging; Ferroelectric devices -- Periodicals; Integrated circuits -- Periodicals; 537.244805
• DOI: 10.1080/10584587.2019.1592601
• Languages: English
• ISSNs: 1058-4587

Abstract

Abstract: Dendrimers have become effective drug carriers and gene transfection vectors for medical biomaterials. In this experiment, UCNPs (NaGdF4 :Tm, Yb@NaGdF4 ) and three-generation PAMAM dendrimers were prepared firstly; then NaGdF4 :Tm, Yb@NaGdF4 was modified by Polyacrylic acid(PAA); PAMAM were grafted to the surface of the modified UCNPs by the reaction between amino groups and carboxyl groups; finally, O-nitrobenzaldehyde was grafted to the surface by Schiff base reaction.The synthesized upconversion materials were coated with PAA and PAMAM, then loaded with O-nitrobenzaldehyde to form spherical nanoparticles. The particle size of prepared nanoparticles is 75 ∼ 80 nm. The dendrimer complex can emit ultraviolet light to regulate the pH gradient of aqueous solution under the excitation of near-infrared light (980 nm), and can be used to kill cancer cells by changing the acidity of tissue cells; secondly, the cavity between dendrimers and dendrimers on the surface of the complex can be used in many fields such as drug delivery and gene transfection; the nanoparticles provide a new method for cancer treatment.