Synthesis of dimeric and tetrameric trithiomannoside clusters through convenient photoinitiated thiol-ene click protocol for efficient inhibition of gram-negative bacteria. Issue 1 (31st March 2021)

• Record Type: Journal Article
• Authors: Mahadevegowda, Surendra H.; Ruan, Lin; Zhang, Jianhua; Hou, Shuai; Raju, Cheerlavancha; Chan-Park, Mary B.
• Is Part Of: Journal of carbohydrate chemistry. Volume 40:Issue 1/3(2021)
• Page Start: 83
• Page End: 96
• Publication Date: 2021-03-31
• Subjects: Bacterial inhibition -- click chemistry -- glycocluster -- molecular recognition; Carbohydrates -- Periodicals; 547.78
• DOI: 10.1080/07328303.2021.1928154
• Languages: English
• ISSNs: 0732-8303

Abstract

Abstract: Glycoclusters with high glycan density accessible through grouping of monosaccharide units in multimeric forms are important due to their high affinity and capability in recognition with protein receptors as a result of multivalent effect. In this report, we have achieved the assembly of glycoclusters in dimeric to tetrameric forms using efficient light initiated free radical mediated thiol-ene click reaction. Bacterium (UTI89) inhibition study by yeast agglutination assay demonstrated that these multivalent glycoclusters showed more efficient inhibition of bacteria when compared to monovalent sugar units. Graphical Abstract: UF0001