Large Tumefactive IgG4-related Disease: Histologic, Cytologic, and Immunohistochemical Features of a Very Unusual Case. Issue 3 (March 2020)

• Record Type: Journal Article
• Authors: Akhtar, Israh; Shenoy, Veena; Khan, Majid; Saad, Ali G.
• Is Part Of: Applied immunohistochemistry & molecular morphology. Volume 28:Issue 3(2020)
• Publication Date: 2020-03
• Subjects: IgG4-related disease -- retroperitoneal mass -- soft tissue tumor; Diagnostic immunohistochemistry -- Periodicals; Immunohistochemistry -- Periodicals; Cells -- Morphology -- Periodicals; Molecular diagnosis -- Periodicals; 616.079
• DOI: 10.1097/PAI.0000000000000571
• Languages: English
• ISSNs: 1541-2016

Abstract

Abstract : Immunoglobulin G4-related disease (IgG4-RD) is a regional or systemic multiorgan lymphoplasmacytic inflammatory disease of unknown etiology. It has been described in numerous organs and anatomic locations. Review of the literature shows that when the disease involves the retroperitoneum it causes retroperitoneal fibrosis. Tumefactive IgG4-RD of the retroperitoneum has not been previously reported. In this report, we describe the first case of a large retroperitoneal tumefactive IgG4-RD along with its histologic, cytologic, and immunohistochemical characteristics.