68Ga–Prostate-Specific Membrane Antigen Uptake in Cerebral Tuberculosis. (March 2020)

• Record Type: Journal Article
• Authors: Wong, Veronica Chi Ken; Shen, Lily; Nasser, Elias; Adams, David Nicholas; Mansberg, Robert
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 3(2020)
• Publication Date: 2020-03
• Subjects: 68Ga–prostate-specific membrane antigen -- cerebral tuberculosis -- prostate cancer; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002910
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 71-year-old man with a history of high-risk prostate adenocarcinoma (Gleason score 4 + 5 = 9) treated with brachytherapy in 2016 was referred for a 68 Ga–prostate-specific membrane antigen (PSMA)–HBED–CC PET/CT scan for suspected cancer recurrence on a background of slowly rising serum prostate-specific antigen (0.95 ng/mL; reference, <0.2 ng/mL). This revealed PSMA-avid dura-based hyperdense lesions in the brain, suggestive of cerebral metastases. Biopsy demonstrated the presence of acid-fast bacilli, and with further clinical and microbiological testing, a diagnosis of PSMA-avid cerebral tuberculous mycobacterium infection was made.