Update on chronic intestinal pseudo-obstruction. Issue 3 (May 2020)

• Record Type: Journal Article
• Authors: Zenzeri, Letizia; Tambucci, Renato; Quitadamo, Paolo; Giorgio, Valentina; De Giorgio, Roberto; Di Nardo, Giovanni
• Is Part Of: Current opinion in gastroenterology. Volume 36:Issue 3(2020)
• Publication Date: 2020-05
• Subjects: adult intestinal pseudo-obstruction -- adults -- children -- chronic intestinal pseudo-obstruction -- gastrointestinal motility -- intestinal failure -- small bowel motility disorders; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1097/MOG.0000000000000630
• Languages: English
• ISSNs: 0267-1379

Abstract

Abstract : Purpose of review: Chronic intestinal pseudo-obstruction (CIPO) is the most severe and disabling form of gastrointestinal dysmotility characterized by an impairment of coordinated propulsive activity in the gastrointestinal tract mimicking mechanical intestinal obstruction. Over the last few years, major advances have been made in the diagnostic and therapeutic management of this rare disorder. Recent findings: The present narrative review aims to summarize the current literature about the management of CIPO focusing on significant novelties about definition, epidemiology, diagnosis, and therapeutic options. The most significant advancement is a consensus on classification and dedicated diagnostic criteria for CIPO in children highlighting the distinctive features between adult and pediatric forms of CIPO (hence pediatric intestinal pseudo-obstruction). Despite no single diagnostic test is pathognomonic of CIPO and no recommended drug treatment is advised to improve gastrointestinal motility, recent reports suggest promising results in both diagnostic testing and therapy that might assist the diagnosis and help the management of patients with CIPO. Summary: The articles referenced in this review will help in optimizing the clinical management of this rare and severe disease in adult population.