PAW22 Does cortical atrophy take place after basal ganglia damage in multiple system atrophy and progressive supranuclear palsy?. Issue 11 (22nd October 2010)

• Record Type: Journal Article
• Authors: Guevara, C; Deasy, N; Payan, C A; Jarosz, J; Agid, Y; Leigh, P N; Ludolph, A; Kempton, M J; Barker, G; Bensimon, G
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 81:Issue 11(2010)
• Page Start: e30
• Page End: e30
• Publication Date: 2010-10-22
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.2010.226340.51
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Magnetic resonance imaging (MRI) has the potential to aid characterise of disease progression in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Methods: Six patients with probable MSA (mean age (years±SD) was 61±10.4) and 7 with PSP (64.7±5.9 years) according to NNIPPS criteria were prospectively recruited for MRI scanning at King's College Hospital. Illness duration at baseline was 5.6±2 (MSA) and 3.72±2.6 (PSP), and at follow-up 8.29±1.7 and 6.58±2.7, respectively; assessment intervals were 2.6±0.2 (MSA) and 2.8±0.3. SIENA was used to estimate local and global brain volume change between MRI at each timepoint, by co-registering and segmenting the images and calculating displacement of the brain/nonbrain boundary. Results: Annual global brain atrophy was 1.27±0.6% (MSA) and 1.5±0.7% (PSP). In PSP, localised grey matter atrophy was detected in left superior temporal gyrus, right parahippocampal gyrus, left nucleus dentate, left cerebellar tonsil and right semilunar cerebellum. In MSA, left superior, middle frontal gyrus and right frontopolar regions were affected. Discussion: Progressive atrophy was found in frontal and temporal cortices in both disorders; the absence of change in striatum and pallidum may reflect already severely damage at baseline.