Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study. (28th January 2021)

• Record Type: Journal Article
• Authors: Hensley, Matthew K; Bain, William G; Jacobs, Jana; Nambulli, Sham; Parikh, Urvi; Cillo, Anthony; Staines, Brittany; Heaps, Amy; Sobolewski, Michele D; Rennick, Linda J; Macatangay, Bernard J C; Klamar-Blain, Cynthia; Kitsios, Georgios D; Methé, Barbara; Somasundaram, Ashwin; Bruno, Tullia C; Cardello, Carly; Shan, Feng; Workman, Creg; Ray, Prabir; Ray, Anuradha; Lee, Janet; Sethi, Rahil; Schwarzmann, William E; Ladinsky, Mark S; Bjorkman, Pamela J; Vignali, Dario A; Duprex, W Paul; Agha, Mounzer E; Mellors, John W; McCormick, Kevin D; Morris, Alison; Haidar, Ghady;
• Is Part Of: Clinical infectious diseases. Volume 73:Number 3(2021)
• Page Start: e815
• Page End: e821
• Publication Date: 2021-01-28
• Subjects: COVID-19 -- SARS-CoV-2 immune responses -- SARS-CoV-2 RNAemia -- SARS-CoV-2 intrahost variation -- SARS-CoV-2 infectivity -- severe acute respiratory syndrome coronavirus 2; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab072
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 10 10 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.