RTEX: A novel framework for ranking, tagging, and explanatory diagnostic captioning of radiography exams. (21st April 2021)

• Record Type: Journal Article
• Authors: Kougia, Vasiliki; Pavlopoulos, John; Papapetrou, Panagiotis; Gordon, Max
• Is Part Of: Journal of the American Medical Informatics Association. Volume 28:Number 8(2021)
• Page Start: 1651
• Page End: 1659
• Publication Date: 2021-04-21
• Subjects: deep learning -- information storage and retrieval -- diagnostic imaging -- diagnostic captioning -- computer-assisted diagnosis -- explainability; Medical informatics -- Periodicals; Information Services -- Periodicals; Medical Informatics -- Periodicals; Médecine -- Informatique -- Périodiques; Informatica; Geneeskunde; Informatique médicale; Computer network resources; Electronic journals; 610.285
• DOI: 10.1093/jamia/ocab046
• Languages: English
• ISSNs: 1067-5027

Abstract

Abstract: Objective: The study sought to assist practitioners in identifying and prioritizing radiography exams that are more likely to contain abnormalities, and provide them with a diagnosis in order to manage heavy workload more efficiently (eg, during a pandemic) or avoid mistakes due to tiredness. Materials and Methods: This article introduces RTEx, a novel framework for (1) ranking radiography exams based on their probability to be abnormal, (2) generating abnormality tags for abnormal exams, and (3) providing a diagnostic explanation in natural language for each abnormal exam. Our framework consists of deep learning and retrieval methods and is assessed on 2 publicly available datasets. Results: For ranking, RTEx outperforms its competitors in terms of nDCG@k . The tagging component outperforms 2 strong competitor methods in terms of F1. Moreover, the diagnostic captioning component, which exploits the predicted tags to constrain the captioning process, outperforms 4 captioning competitors with respect to clinical precision and recall. Discussion: RTEx prioritizes abnormal exams toward the improvement of the healthcare workflow by introducing a ranking method. Also, for each abnormal radiography exam RTEx generates a set of abnormality tags alongside a diagnostic text to explain the tags and guide the medical expert. Human evaluation of the produced text shows that employing the generated tags offers consistency to the clinical correctness and that the sentences of each text have high clinical accuracy. Conclusions: This is the first framework that successfully combines 3 tasks: ranking, tagging, and diagnostic captioning with focus on radiography exams that contain abnormalities.