A comparison of an effect of different anti-inflammatory drugs on human platelets. Issue 6 (September 1970)

• Record Type: Journal Article
• Authors: O'Brien, J. R.; Finch, Wendy; Clark, Elizabeth
• Is Part Of: Journal of clinical pathology. Volume 23:Issue 6(1970)
• Page Start: 522
• Page End: 525
• Publication Date: 1970-09
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.23.6.522
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Different doses of aspirin, indomethacin, paracetamol, benorylate, and sodium salicylate were taken by four volunteers. The minimal dose that altered a platelet function test and the persistence of this alteration at different dose levels were studied. Minute doses of indomethacin (0·035 mg/kg) were effective but the effect of even a large single dose did not persist. A tenth of the therapeutic dose of aspirin (1 mg/kg) was effective, and higher doses altered the platelets' function for several days. Benorylate in a high therapeutic dose gave aspirin-like results. Paracetamol and sodium salicylate were relatively inactive. The persistence of the aspirin effect may be related to the acetyl group. These findings are surveyed in relation to a general theory of the action of anti-inflammatory drugs.