Acute renal failure due to sulphadiazine crystalluria in AIDS patients. Issue 851 (September 1996)

• Record Type: Journal Article
• Authors: de Sequera, P.; Albalate, M.; Hernandez, J.; Vazquez, A.; Abad, J.; Ramiro, E.; Fernández Guerrero, M.; Caramelo, C.; Casado, S.; Ortiz, A.
• Is Part Of: Postgraduate medical journal. Volume 72:Issue 851(1996)
• Page Start: 557
• Page End: 558
• Publication Date: 1996-09
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.72.851.557
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : We report two AIDS patients who developed acute renal failure while receiving sulphadiazine for cerebral toxoplasmosis. Renal ultrasound revealed diffuse bilateral echogenic shadowing material. 'Sheaves of wheat' crystals, typical of sulphadiazine crystalluria, were present in the urine. One patient required a percutaneous nephrostomy. Hydration and urine alkalinisation resulted in rapid improvement of renal function and ultrasonographic findings. Sulphadiazine-induced crystalluria and acute renal failure is increasingly frequent. Awareness of its existence may lead to prevention and early conservative treatment.