Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size. Issue 6 (1st June 2002)

• Record Type: Journal Article
• Authors: Licka, M; Zimmermann, R; Zehelein, J; Dengler, T J; Katus, H A; Kübler, W
• Is Part Of: Heart. Volume 87:Issue 6(2002)
• Page Start: 520
• Page End: 524
• Publication Date: 2002-06-01
• Subjects: acute myocardial infarction -- infarct size -- troponin T -- creatine kinase -- thallium-201 scintigraphy; CK, creatine kinase -- CK-MB, creatine kinase MB isoenzyme -- ELISA, enzyme linked immunosorbent assay -- LDH, lactate dehydrogenase -- SPECT, single photon emission computed tomography -- TnT, troponin T; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heart.87.6.520
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Background: After acute myocardial infarction, the structural protein T is released considerably longer than cytosolic creatine kinase (CK), CK MB isoenzyme (CK-MB), or lactate dehydrogenase (LDH) and late troponin T release (> 48 hours after onset of chest pain) appears to be less affected by early coronary reperfusion. Objective: To investigate the precision of a single measurement of circulating troponin T concentrations 72 hours after onset of chest pain compared with standard scintigraphic and enzymatic estimates of myocardial infarct size. Methods: Quantitative single photon emission computed tomography thallium-201 scintigraphy at rest was performed in 37 patients 2–3 weeks after myocardial infarction (group 1: 14 patients without early coronary reperfusion; group 2: 23 patients with early reperfusion achieved by thrombolytic therapy, by percutaneous transluminal coronary angioplasty, or by both). Results: In both groups, the number of myocardial segments with abnormal thallium-201 uptake indicating the individual extent of irreversible myocardial damage correlated significantly with the troponin T concentrations 72 hours after infarction as well as with peak concentrations of CK, CK-MB, and LDH. Conclusion: The data show that a single measurement of circulating troponin T 72 hours after onset of chest pain—independent of reperfusion—is superior for the estimation of myocardial infarct size to measurement of peak CK, CK-MB, or LDH, which require serial determinations and depend on coronary reperfusion.