Evaluating ibrutinib for the treatment of relapsed/refractory marginal zone lymphoma. (2nd September 2021)

• Record Type: Journal Article
• Authors: Cavalloni, Chiara; Varettoni, Marzia; Rattotti, Sara; Arcaini, Luca
• Is Part Of: Expert opinion on pharmacotherapy. Volume 22:Number 13(2021)
• Page Start: 1643
• Page End: 1649
• Publication Date: 2021-09-02
• Subjects: Marginal zone lymphoma -- bruton tyrosine kinase -- indolent non hodgkin lymphoma -- targeted therapy; Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1080/14656566.2021.1941864
• Languages: English
• ISSNs: 1465-6566

Abstract

ABSTRACT: Introduction : Marginal zone lymphoma (MZL) is a heterogeneous disease with a wide range of possible frontline therapies depending on the subtype; there are no shared guidelines for the treatment of relapsed/refractory MZLs. The growing evidence of the importance of the BCR pathway in the pathogenesis of B lymphoproliferative forms has led researchers to consider BTK as a potential therapeutic target in MZL. Area covered : The authors provide the reader with an evaluation of ibrutinib as a treatment option for refractory marginal zone lymphoma. The review includes an overview of the drug's pharmacokinetics and pharmacodynamics, efficacy, and safety. The authors also provide the reader with their expert perspectives on the drug and its place in the treatment of MZL. Expert opinion : The availability of new non-chemotherapeutic agents represents an important opportunity to spare excessive exposure to cytotoxic compounds. Immunomodulators and targeted agents, alone or often in combination with immunotherapy, have been shown to be effective and safe therapies in patients with relapsed/refractory (R/R) MZL. In addition, numerous studies involving new generation targeted agents, alone or in combination, are currently active in both R/R and untreated patient populations, some with encouraging preliminary results.