Child reward neurocircuitry and parental substance use history: Findings from the Adolescent Brain Cognitive Development Study. (November 2021)

• Record Type: Journal Article
• Authors: Kwarteng, Amy E.; Rahman, Muhammad M.; Gee, Dylan G.; Infante, M. Alejandra; Tapert, Susan F.; Curtis, Brenda L.
• Is Part Of: Addictive behaviors. Volume 122(2021)
• Publication Date: 2021-11
• Subjects: ABCD Study -- fMRI -- Monetary Incentive Delay task -- Substance use history -- Reward anticipation; Substance abuse -- Periodicals; Alcoholism -- Periodicals; Drug addiction -- Periodicals; Nicotine addiction -- Periodicals; Smoking -- Periodicals; Gambling -- Psychological aspects -- Periodicals; Electronic journals; 362.29
• DOI: 10.1016/j.addbeh.2021.107034
• Languages: English
• ISSNs: 0306-4603

Abstract

Highlights: More accumbens activity was found in youth with a parent history of alcohol abuse. Greater putamen activity was found among youth with a parent history of drug abuse. Parent history for substance problems appears to impact reward system activity. Abstract: Background: Substance use research has focused on family history of alcohol use disorders but less on other addictions in biological family members. We examined how parental substance use history relates to reward system functioning, specifically nucleus accumbens (NAcc) and putamen activation at age 9–10 in the Adolescent Brain Cognitive Development (ABCD) Study. This research hopes to address limitations in prior literature by focusing analyses on a large, substance-naïve sample. Method: We included ABCD participants with valid Monetary Incentive Delay task fMRI Baseline data and parent substance use history at project baseline from Data Release 2.0 (N = 10, 622). Parent-history-positive (PH+) participants had one or both biological parents with a history of two+problems with alcohol (n = 741; PH+A) and/or other drugs (n = 638; PH+D). Of participants who were parent-history-negative (PH-) for alcohol and/or drugs, a stratified random sample based on six sociodemographic variables was created and matched to the PH+group (PH-A n = 699; PH-D n = 615). The contrast of interest was anticipation of a large reward vs. neutral response. Results: PH+A youth had more activation in the right NAcc during large reward anticipation than PH-A. PH+D youth showed enhanced left putamen activation during large reward anticipation than PH-D youth. Bayesian hypothesis testing showed moderate evidence (BF > 3) in favor of the null hypothesis. Conclusion: These findings suggest that pre-adolescents whose biological parents had a history of substance-related problems show small differences in reward processing compared to their PH- peers.