Inflammatory cytokines during a manic episode in bd patients and its correlation with cognitive and affective symptoms at follow-up. (13th April 2021)

• Record Type: Journal Article
• Authors: Guerra, M. Estudillo; Suarez, G. Torres; Mesia-Toledo, I.; Pacheco-Barrios, K.; Ramírez-Bemúdez, J.
• Is Part Of: European psychiatry. Volume 64:Supplement 1(2021)
• Page Start: S624
• Page End: S625
• Publication Date: 2021-04-13
• Subjects: cytokines -- manía -- cognition -- bipolar disorder; Psychiatry -- Periodicals; Mental illness -- Periodicals; Electronic journals; 616.89
• DOI: 10.1192/j.eurpsy.2021.1660
• Languages: English
• ISSNs: 0924-9338

Abstract

Abstract : Introduction: Bipolar Disorder (BD) is a severe recurrent disorder with a complex biogenetic and psychosocial etiology. The immune system cytokines in interaction with the CNS play a role in the pathophysiology. Objectives: To compare inflammatory cytokines between BD patients and controls during the manic episode; additionally, compare these cytokines with psychiatric symptoms and cognitive performance during follow-up. Methods: We recruited 25 BD patients in mania with paired controls. We measured baseline IL-2, IL-4, IL-8, IL-10, GM-CSG, TNF- α, and TNF- γ in plasma. We used U-Mann-Whitney for group comparison and Spearman correlation between sub-group follow-up assessments and cytokines. Results: We found a significant difference in IL-6 between subjects and controls (figure 1). During the follow-up, we found a correlation with psychiatric symptoms, cognition, and cytokines during manic episodes (Table 1). Table 1. Follow-up Correlation with cytokines during a manic episode. BD follow-up N=8 Cytokine MADRS BPRS SCIP-S WMT-SCIP-S PST-SCIP-S IL-10 (-) Rho=-.957 (p=<0.001 R2=0.14). IL-4 (+) Rho=.78 (p=0.02 R2=0.09) INF- γ (+) Rho=.73 (p=0.03 R2= 0.48) (+) Rho=.751 (p=0.032 R2=0.53) (+) Rho=.737 (p=.037 R2=0.40) INF- α (+) Rho=.887 (p=.003 R2=0.53), (+) Rho=.830 (p=0.011 R2=0.59) (+): positive correlation; (-): negative correlation. WMT: working-memory test, PST: Processing-speed test. Conclusions: IL-6 was significantly different in patients with BD during a manic episode regardless of the treatment they were taking. IL-10 at manic episode was negatively correlated to general psychiatric symptoms, IL-4 positive correlated to depressive symptoms, and cognitive performance was positively correlated to TNF- α and TNF- γ at follow-up. Disclosure: No significant relationships.