Absence of paraneoplastic antineuronal antibodies in sera of 145 patients with motor neuron disease. Issue 8 (21st February 2007)

• Record Type: Journal Article
• Authors: Stich, Oliver; Kleer, Barbara; Rauer, Sebastian
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 78:Issue 8(2007)
• Page Start: 883
• Page End: 885
• Publication Date: 2007-02-21
• Subjects: ALS, amyotrophic lateral sclerosis -- ANAbs, antineuronal antibodies -- LMN, lower motor neuron -- MND, motor neuron disease -- OD, optical density -- PNS, paraneoplastic neurological syndromes; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.2006.097774
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Background: Well characterised antineuronal antibodies (ANAbs) have been shown to be highly specific markers of neurological syndromes with a paraneoplastic aetiology. Previous reports indicate that pure motor neuron disease (MND) is rarely of paraneoplastic origin. Objective: To screen systematically for the prevalence of well characterised paraneoplastic ANAbs in a large collective of patients with pure MND. Methods: In a cohort of 145 patients with MND, the frequency of ANAbs was estimated by ELISA, employing recombinant antigens (HuD, Yo, Ri, CV2/CRMP5, Ma2 and amphiphysin). Results: None of the sera revealed high antineuronal antigen reactivity. Very low reactivity was detected in only five sera, in all probability representing background activity. Conclusion: According to these data, routine analysis for ANAbs in patients with isolated MND is not mandatory.