A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour. Issue 5 (27th April 2004)

• Record Type: Journal Article
• Authors: Hansma, A H G; van Hensbergen, Y; Kuenen, B C; van Diest, P J; Hanemaaijer, R; Meijer, S; Pinedo, H M; Hoekman, K
• Is Part Of: Journal of clinical pathology. Volume 57:Issue 5(2004)
• Page Start: 536
• Page End: 538
• Publication Date: 2004-04-27
• Subjects: gastrointestinal autonomic nerve tumour -- vascular endothelial growth factor -- endostatin -- tumour fluid; bFGF, basic fibroblast growth factor -- ELISA, enzyme linked immunosorbent assay -- GANT, gastrointestinal autonomic nerve tumour -- MMP, matrix metalloprotease -- ms-mono, mouse monoclonal antibody -- NSE, neurone specific enolase -- PS, plasminogen activator -- STS, soft tissue sarcomas -- tPA, tissue plasminogen activator -- uPA, urokinase plasminogen activator -- VEGF, vascular endothelial growth factor; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2003.012393
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Tumour associated neovascularisation has been characterised as chaotic and insufficient. This report details the results of the analysis of angiogenic factors in tumour cyst fluid, pleural fluid, and blood from a patient with a gastrointestinal autonomic nerve tumour. The tumour produced vascular endothelial growth factor and endostatin in large quantities, which may explain the dysfunctional angiogenesis and tendency to bleeding seen in this tumour type.