Pulmonary macrophages: key players in the innate defence of the airways. Issue 12 (18th August 2015)

• Record Type: Journal Article
• Authors: Byrne, Adam J; Mathie, Sara A; Gregory, Lisa G; Lloyd, Clare M
• Is Part Of: Thorax. Volume 70:Issue 12(2015)
• Page Start: 1189
• Page End: 1196
• Publication Date: 2015-08-18
• Subjects: Innate Immunity -- Macrophage Biology -- Idiopathic pulmonary fibrosis -- Cystic Fibrosis -- COPD Exacerbations -- Bacterial Infection -- Asthma Mechanisms -- Respiratory Infection; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2015-207020
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Macrophages are the most numerous immune-cells present in the lung environment under homoeostatic conditions and are ideally positioned to dictate the innate defence of the airways. Pulmonary macrophage populations are heterogeneous and demonstrate remarkable plasticity, owing to variations in origin, tissue residency and environmental influences. Lung macrophage diversity facilitates considerable specialisation, aids efficient responses to environmental signals and allows rapid alterations in phenotype and physiology in response to a plethora of cytokines and microbial signals. This review describes pulmonary macrophage origins, phenotypes, roles in diseases of the airways and implications for the treatment of respiratory disease.