Age-Related Differences in the Prognosis of Pancreatic Cancer According to Perioperative Systemic Therapy. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Sonohara, Fuminori; Yamada, Suguru; Kurimoto, Keisuke; Inokawa, Yoshikuni; Takami, Hideki; Hayashi, Masamichi; Shimizu, Dai; Hattori, Norifumi; Kanda, Mitsuro; Tanaka, Chie; Nakayama, Goro; Koike, Masahiko; Fujii, Tsutomu; Kodera, Yasuhiro
• Is Part Of: Pancreas. Volume 50:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: pancreatic cancer -- elderly patients -- preoperative therapy, postoperative therapy -- prognosis; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000001712
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: In this study, we retrospectively assessed the feasibility and prognostic efficacy of perioperative chemo(radio)therapy for pancreatic cancer (PC) patients according to age. Methods: A total of 556 consecutive patients who underwent curative-intent pancreatectomy for PC between 2000 and 2018 were enrolled. Results: Of the 556 patients who underwent resection, 95 (17%) were elderly (age, ≥75 years). Postoperative complications did not significantly differ between the 2 age groups, and postoperative prognoses were also similar (recurrence-free survival [RFS], P = 0.68; overall survival [OS], P = 0.28). In this cohort, 103 patients (19%) underwent preoperative chemo(radio)therapy, and 417 (77%) underwent postoperative chemotherapy. Perioperative therapy was found to be significantly beneficial for younger patients (preoperative therapy: RFS, P = 0.006; OS, P < 0.001; postoperative therapy: RFS, P < 0.001; OS, P < 0.001). Conversely, no significant survival benefit of perioperative therapy was found for the elderly (preoperative therapy: RFS, P = 0.28; OS, P = 0.44; postoperative therapy: RFS, P = 0.77; OS, P = 0.08). Conclusions: This study demonstrated that, although perioperative therapy is feasible for selected elderly patients with PC, this approach might not be as beneficial as it is for younger PC patients. Abstract : Supplemental digital content is available in the text.