Effectiveness of highly active antiretroviral therapy among HIV-1 infected women. (1st February 2002)

• Record Type: Journal Article
• Authors: Gange, S J; Barrón, Y; Greenblatt, R M; Anastos, K; Minkoff, H; Young, M; Kovacs, A; Cohen, M; Meyer, W A; Muñoz, A
• Other Names: group-author.
• Is Part Of: Journal of epidemiology and community health. Volume 56(2002)Supplement 2
• Page Start: 153
• Page End: 159
• Publication Date: 2002-02-01
• Subjects: HIV -- AIDS -- antiretroviral therapy -- cohort study; HAART, highly active antiretroviral therapy -- RTIs, reverse transcriptase inhibitors -- ART, antiretroviral therapy -- WIHS, Women's Interagency HIV Study; Public health -- Periodicals; Epidemiology -- Periodicals; 614.4
• DOI: 10.1136/jech.56.2.153
• Languages: English
• ISSNs: 0143-005X

Abstract

Abstract : Study objective: To describe the impact of highly active antiretroviral therapy (HAART) on mortality, morbidity, and markers of HIV disease progression in HIV infected women. Design: Data collected from the Women's Interagency HIV Study, a prospective cohort study that enrolled women between October 1994 and November 1995. Setting: Six clinical consortia based in five cities in the United States (New York, NY; Washington, DC; Los Angeles, CA; San Francisco, CA; and Chicago, IL). Participants: A total of 1691 HIV seropositive women with a study visit after April 1996. Main results: Beginning in April 1996, the self reported use of HAART increased over time, with more than 50% of the cohort reporting HAART use in 1999. There was a 23% decline per semester in the incidence of AIDS from April 1996 (95% confidence intervals (CI) −29% to −16%). Furthermore, there was a 21% decline of the semiannual mortality rates among those with AIDS at baseline (95% CI −27% to −14%) and an 11% decline among those AIDS free at baseline (95% CI −3% to −18%). CD4+ lymphocyte counts either increased (women with baseline AIDS) or stabilised (women without baseline AIDS) after April 1996, and HIV RNA levels dramatically declined in both groups, although the percentage of women with HIV RNA above 4000 cps/ml remained stable at approximately 40% since mid-1997. Conclusions: Despite concerns regarding the use of antiretroviral therapies in this population, the use of therapies led to improved immunological function, suppressed HIV disease activity, and dramatic declines in morbidity and mortality.