Jejunal lysozyme activity and the Paneth cell in coeliac disease. Issue 1 (January 1979)

• Record Type: Journal Article
• Authors: Ward, M; Ferguson, A; Eastwood, M A
• Is Part Of: Gut. Volume 20:Issue 1(1979)
• Page Start: 55
• Page End: 58
• Publication Date: 1979-01
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.20.1.55
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.