Relationship between internalizing and externalizing symptoms trajectories and perinatal risk factors in an epidemiological sample: Preliminary results from the remind project. (13th April 2021)

• Record Type: Journal Article
• Authors: Grazioli, S.; Rosi, E.; Villa, F.; Mauri, M.; Brambilla, P.; Bonivento, C.; Molteni, M.; Nobile, M.
• Is Part Of: European psychiatry. Volume 64:Supplement 1(2021)
• Page Start: S148
• Page End: S149
• Publication Date: 2021-04-13
• Subjects: perinatal risk factors -- internalizing psychopathology -- externalizing psychopathology -- psychopathology trajectories; Psychiatry -- Periodicals; Mental illness -- Periodicals; Electronic journals; 616.89
• DOI: 10.1192/j.eurpsy.2021.406
• Languages: English
• ISSNs: 0924-9338

Abstract

Abstract : Introduction: Our 15-years follow-up ReMIND project aims to re-assess an epidemiological and a clinical sample of adults (Wave 3), who were assessed in preadolescence (Wave 1) and adolescence (Wave 2), to evaluate symptoms trajectories and their relationship with genetic/epigenetic data, environmental risk factors and neuroimaging measures. Objectives: Here, we depict preliminary results regarding the epidemiological sample. Methods: We assessed internalizing and externalizing symptoms in 40 italian subjects (25 F) from general population at three waves (W1 mean age: 12±0, 82; W2 mean age: 17±0, 88, W3 mean age: 28±1), through the Child Behavior Checklist (W1 and W2) or the Adult Self Report (W3), and perinatal risk factors through a socio-anamnestic questionnaire, by a new online platform (MedicalBit). We analyzed symptoms trajectories and their relation with perinatal risk factors through a repeated measures multivariate analysis of variance (rm-MANOVA). Results: rm-MANOVA results show that high number of perinatal risks was significantly associated with higher internalizing symptomatology in preadolescence but not in adolescence and adult life. The mean difference was 8 T-points. The same trend is evident in adolescence but not in adult age (Graph 1). Perinatal risk factors did not have a significant effect on externalizing symptoms at any time point, despite a non-significant trend is evident (Graph 2). Conclusions: Our preliminary results suggest a trend of increased internalizing symptoms from childhood to adulthood and a significant role of perinatal risk factors in pre-adolescence. Further investigations are necessary to better understand symptoms trajectories and the role of biological and environmental factors. Disclosure: No significant relationships.