Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags. Issue 1 (20th August 2015)

• Record Type: Journal Article
• Authors: Ramdas, Sagar; Yousaf, Farzana; Shastri, Madhur D; Wanandy, Troy; Zaidi, Syed T R; Khandagale, Manish; Jose, Matthew; Patel, Rahul P
• Is Part Of: European journal of hospital pharmacy. Volume 23:Issue 1(2016)
• Page Start: 57
• Page End: 60
• Publication Date: 2015-08-20
• Subjects: Pharmacy -- Periodicals; Hospital pharmacies -- Periodicals; 615.1
• DOI: 10.1136/ejhpharm-2015-000651
• Languages: English
• ISSNs: 2047-9956

Abstract

Abstract : Background: Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution. Methods: Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25°C for up to 168 h or 37°C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography. Results: Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4°C, 25°C and 37°C, respectively. No physical precipitation or pH change was observed during the study. Conclusions: Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4°C and 37°C, respectively.