Immunophenotype and function define TCRγδ + T-ALL as a distinct subgroup from TCRαβ + T-ALL patients. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Mirji, Gauri; Banavali, Shripad; Sengar, Manju; Chiplunkar, Shubhada V.
• Is Part Of: Leukemia & lymphoma. Volume 61:Issue 1(2020)
• Page Start: 108
• Page End: 117
• Publication Date: 2020-01-02
• Subjects: TCRγδ + T-ALL -- γδ T cells -- immunophenotype -- memory T cells -- immune synapse -- perforin; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2019.1650174
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: We recently demonstrated TCRγδ + T-ALL as a distinct subgroup from TCRαβ + T-ALL at genomic level. TCRγδ + T-ALL subgroup possess significant survival advantage compared to TCRαβ + T-ALL. In the present study, functional level differences in these two subgroups of T-ALL were studied to understand the immune scenario contributing to survival benefit of TCRγδ + T-ALL subgroup. TCRγδ clonal T-ALL patients showed significantly high levels of γδ T cells compared to TCRαβ clonal T-ALL patients. TCRγδ + T-ALL patients expressed significantly high central memory and terminally differentiated (TemRA) Vδ1 and Vδ2 T cells. TCR γδ clonal leukemic blasts stimulated increased number of Vδ2 T cells from healthy lymphocytes. TCR γδ clonal leukemic blasts were able to form efficient immune synapse with effector γδ T cells. The differences in immunophenotype, cytotoxicity and immune synapse formations corroborate TCRγδ + T-ALL as a distinct subgroup from TCRαβ + T-ALL patients and explain the survival benefit of TCRγδ + T-ALL patients.