Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. Issue 3 (22nd December 2019)

• Record Type: Journal Article
• Authors: Glynn, Nancy W.; Gmelin, Theresa; Santanasto, Adam J.; Lovato, Laura C.; Lange‐Maia, Brittney S.; Nicklas, Barbara J.; Fielding, Roger A.; Manini, Todd M.; Myers, Valerie H.; de Rekeneire, Nathalie; Spring, Bonnie J.; Pahor, Marco; King, Abby C.; Rejeski, W. Jack; Newman, Anne B.
• Other Names: Pahor Marco investigator.; Guralnik Jack M. investigator.; Anton Stephen D. investigator.; Buford Thomas W. investigator.; Leeuwenburgh Christiaan investigator.; Nayfield Susan G. investigator.; Manini Todd M. investigator.; Caudle Connie investigator.; Crump Lauren investigator.; Holmes Latonia investigator.; Lee Jocelyn investigator.; Lu Ching‐ju investigator.; Miller Michael E. investigator.; Espeland Mark A. investigator.; Ambrosius Walter T. investigator.; Applegate William investigator.; Beavers Daniel P. investigator.; Byington Robert P. investigator.; Cook Delilah investigator.; Furberg Curt D. investigator.; Harvin Lea N. investigator.; Henkin Leora investigator.; Hepler John investigator.; Hsu Fang‐Chi investigator.; Joyce Kathy investigator.; Lovato Laura investigator.; Pierce Juan investigator.; Roberson Wesley investigator.; Robertson Julia investigator.; Rushing Julia investigator.; Rushing Scott investigator.; Stowe Cynthia L. investigator.; Walkup Michael P. investigator.; Hire Don investigator.; Rejeski W. Jack investigator.; Katula Jeffrey A. investigator.; Brubaker Peter H. investigator.; Mihalko Shannon L. investigator.; Jennings Janine M. investigator.; Chen Shyh‐Huei investigator.; Pierce June J. investigator.; Chen Haiying investigator.; Hadley Evan C. investigator.; Romashkan Sergei investigator.; Patel Kushang V. investigator.; Bethesda investigator.; Bonds Denise investigator.; McDermott Mary M. investigator.; Spring Bonnie investigator.; Hauser Joshua investigator.; Kerwin Diana investigator.; Domanchuk Kathryn investigator.; Graff Rex investigator.; Rego Alvito investigator.; Church Timothy S. investigator.; Blair Steven N. investigator.; Myers Valerie H. investigator.; Monce Ron investigator.; Britt Nathan E. investigator.; Harris Melissa Nauta investigator.; McGucken Ami Parks investigator.; Rodarte Ruben investigator.; Millet Heidi K. investigator.; Tudor‐Locke Catrine investigator.; Butitta Ben P. investigator.; Donatto Sheletta G. investigator.; Cocreham Shannon H. investigator.; King Abby C. investigator.; Castro Cynthia M. investigator.; Haskell William L. investigator.; Stafford Randall S. investigator.; Pruitt Leslie A. investigator.; Yank Veronica investigator.; Berra Kathy investigator.; Bell Carol investigator.; Thiessen Rosita M. investigator.; Youngman Kate P. investigator.; Virgen Selene B. investigator.; Maldonado Eric investigator.; Tarin Kristina N. investigator.; Klaftenegger Heather investigator.; Prosak Carolyn A. investigator.; Campero Ines investigator.; Garcia Dulce M. investigator.; Soto José investigator.; Chio Linda investigator.; Hoskins David investigator.; Fielding Roger A. investigator.; Nelson Miriam E. investigator.; Folta Sara C. investigator.; Phillips Edward M. investigator.; Liu Christine K. investigator.; McDavitt Erica C. investigator.; Reid Kieran F. investigator.; Kirn Dylan R. investigator.; Pasha Evan P. investigator.; Kim Won S. investigator.; Krol Julie M. investigator.; Beard Vince E. investigator.; Tsiroyannis Eleni X. investigator.; Hau Cynthia investigator.; Manini Todd M. investigator.; Pahor Marco investigator.; Anton Stephen D. investigator.; Buford Thomas W. investigator.; Marsiske Michael investigator.; Nayfield Susan G. investigator.; Sandesara Bhanuprasad D. investigator.; Black Mieniecia L. investigator.; Burk William L. investigator.; Hoover Brian M. investigator.; Knaggs Jeffrey D. investigator.; Marena William C. investigator.; Korytov Irina investigator.; Curtis Stephanie D. investigator.; Lorow Megan S. investigator.; Goswami Chaitalee S. investigator.; Lewis Melissa A. investigator.; Kamen Michelle investigator.; Bitz Jill N. investigator.; Stanton Brian K. investigator.; Hicks Tamika T. investigator.; Gay Charles W. investigator.; Xie Chonglun investigator.; Morris Holly L. investigator.; Singletary Floris F. investigator.; Causer Jackie investigator.; Yonce Susan investigator.; Radcliff Katie A. investigator.; Smith Mallorey Picone investigator.; Scott Jennifer S. investigator.; Rodriguez Melissa M. investigator.; Fitch Margo S. investigator.; Dunn Mendy C. investigator.; Schllesinger Jessica Q. investigator.; Newman Anne B. investigator.; Studenski Stephanie A. investigator.; Goodpaster Bret H. investigator.; Lopez Oscar investigator.; Glynn Nancy W. investigator.; Nadkarni Neelesh K. investigator.; Ives Diane G. investigator.; Newman Mark A. investigator.; Grove George investigator.; Williams Kathy investigator.; Bonk Janet T. investigator.; Rush Jennifer investigator.; Kost Piera investigator.; Vincent Pamela investigator.; Gerger Allison investigator.; Romeo Jamie R. investigator.; Monheim Lauren C. investigator.; Kritchevsky Stephen B. investigator.; Marsh Anthony P. investigator.; Brinkley Tina E. investigator.; Demons Jamehl S. investigator.; Sink Kaycee M. investigator.; Kennedy Kimberly investigator.; Shertzer‐Skinner Rachel investigator.; Wrights Abbie investigator.; Fries Rose investigator.; Barr Deborah investigator.; Gill Thomas M. investigator.; Axtell Robert S. investigator.; Kashaf Susan S. investigator.; de Rekeneire Nathalie investigator.; McGloin Joanne M. investigator.; Mautner Raeleen investigator.; Huie‐White Sharon M. investigator.; Bianco Luann investigator.; Zocher Janice investigator.; Wu Karen C. investigator.; Shepard Denise M. investigator.; Fennelly Barbara investigator.; Castro Rina investigator.; Halpin Sean investigator.; Brennan Matthew investigator.; Barnett Theresa investigator.; Iannone Lynne P. investigator.; Zenoni Maria A. investigator.; Bugaj Julie A. investigator.; Bailey Christine investigator.; Charpentier Peter investigator.; Hawthorne‐Jones Geraldine investigator.; Mignosa Bridget investigator.; Lewis Lynn investigator.; Williamson Jeff investigator.; Sink Kaycee M investigator.; Hendrie Hugh C. investigator.; Rapp Stephen R. investigator.; Verghese Joe investigator.; Woolard Nancy investigator.; Espeland Mark investigator.; Jennings Janine investigator.; Wilson Valerie K. investigator.; Pepine Carl J. investigator.; Ariet Mario investigator.; Handberg Eileen investigator.; Deluca Daniel investigator.; Hill James investigator.; Szady Anita investigator.; Chupp Geoffrey L. investigator.; Flynn Gail M. investigator.; Gill Thomas M. investigator.; Hankinson John L. investigator.; Vaz Fragoso Carlos A. investigator.; Groessl Erik J. investigator.; Kaplan Robert M. investigator.;
• Is Part Of: Journal of the American Geriatrics Society. Volume 68:Issue 3(2020)
• Page Start: 619
• Page End: 624
• Publication Date: 2019-12-22
• Subjects: fatigability -- older adults -- health education -- exercise; Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.16274
• Languages: English
• ISSNs: 0002-8614

Abstract

Abstract : OBJECTIVES: Our aim was to examine the impacts of baseline fatigue on the effectiveness of a physical activity (PA) intervention to prevent major mobility disability (MMD) and persistent major mobility disability (PMMD) in participants from the Lifestyle Interventions and Independence for Elders (LIFE) study. DESIGN: Prospective cohort of individuals aged 65 years or older undergoing structured PA intervention or health education (HE) for a mean of 2.6 years. SETTING: LIFE was a multicenter eight‐site randomized trial that compared the efficacy of a structured PA intervention with an HE program in reducing the incidence of MMD. PARTICIPANTS: Study participants (N = 1591) at baseline were 78.9 ± 5.2 years of age, with low PA and at risk for mobility impairment. MEASUREMENTS: Self‐reported fatigue was assessed using the modified trait version of the Exercise‐Induced Feelings Inventory, a six‐question scale rating energy levels in the past week. Responses ranged from 0 (none of the time) to 5 (all of the time). Total score was calculated by averaging across questions; baseline fatigue was based on the median split: 2 or higher = more fatigue (N = 856) and lower than 2 = less fatigue (N = 735). Participants performed a usual‐paced 400‐m walk every 6 months. We defined incident MMD as the inability to walk 400‐m at follow‐up visits; PMMD was defined as two consecutive walk failures. Cox proportional hazard models quantified the risk of MMD and PMMD in PA vs HE stratified by baseline fatigue adjusted for covariates. RESULTS: Among those with higher baseline fatigue, PA participants had a 29% and 40% lower risk of MMD and PMMD, respectively, over the trial compared with HE (hazard ratio [HR] for MMD = .71; 95% confidence interval [CI] = .57‐.90; P = .004) and PMMD (HR = .60; 95% CI = .44‐.82; P = .001). For those with lower baseline fatigue, no group differences in MMD ( P = .36) or PMMD ( P = .82) were found. Results of baseline fatigue by intervention interaction was MMD ( P = .18) and PMMD ( P = .05). CONCLUSION: A long‐term moderate intensity PA intervention was particularly effective at preserving mobility in older adults with higher levels of baseline fatigue. J Am Geriatr Soc 68:619–624, 2020