Adherence to a Mediterranean diet and cognitive function in the Age‐Related Eye Disease Studies 1 & 2. Issue 6 (13th April 2020)

• Record Type: Journal Article
• Authors: Keenan, Tiarnán D.; Agrón, Elvira; Mares, Julie A.; Clemons, Traci E.; van Asten, Freekje; Swaroop, Anand; Chew, Emily Y.
• Is Part Of: Alzheimer's & dementia. Volume 16:Issue 6(2020)
• Page Start: 831
• Page End: 842
• Publication Date: 2020-04-13
• Subjects: age‐related macular degeneration -- cognitive function -- fish consumption -- genetic interaction -- Mediterranean diet; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12077
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function. Methods: Observational analyses of participants (n = 7, 756) enrolled in two randomized trials of nutritional supplements for age‐related macular degeneration: Age‐Related Eye Disease Study (AREDS) and AREDS2. Results: Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 ( P = .0001) for Modified Mini‐Mental State (<80) and 0.56 ( P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status‐Modified (<30) and 0.48 for composite score (each P < .0001) in AREDS2. Fish intake was associated with higher cognitive function. In AREDS2, rate of cognitive decline over 5 to 10 years was not significantly different by aMED but was significantly slower ( P = .019) with higher fish intake. Discussion: Closer Mediterranean diet adherence was associated with lower risk of cognitive impairment but not slower decline in cognitive function. Apolipoprotein E ( APOE ) haplotype did not influence these relationships.